POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS

Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also di...

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Hauptverfasser:	SUNIL PALIWAL, SOBHANA BABU BOGA, HONUNG TSUI, YONGQI DENG, TONG WANG, YOUHAO DONG, AZIM A. CELEBI, AHMED SAMATAR, LI XIAO, YANG NAN, GERALD, W. SHIPPS, ALAN COOPER, RONALD DOLL, JOSEPH KELLY, YIJI WU, JAMES WANG, HUGH ZHU, M. ARSHAD SIDDIQUI, ROBERT SUN, NENG-YANG SHIH, JAGDISH DESAI, VINCENT STEWART MADISON, ALAN HRUZA
Format:	Patent
Sprache:	eng ; por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.