MONO-LYSINE SALTS OF AZOLE COMPOUNDS

Mono-lysine salts of triazole compounds having a secondary or tertiary hydroxy group are provided. More particularly, the new water-soluble triazole antifungal mono-lysine salt compounds, or solvates thereof, are provided having the general formula I: wherein A in formula I represents the non-hydrox...

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Hauptverfasser: QI GAO, SUSANNE KIAU, BLISSE VAKKALAGADDA, MICHAEL G. FAKES, YADAGIRI R. PENDRI, CHUNG-PIN H. CHEN
Format: Patent
Sprache:eng ; por
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Zusammenfassung:Mono-lysine salts of triazole compounds having a secondary or tertiary hydroxy group are provided. More particularly, the new water-soluble triazole antifungal mono-lysine salt compounds, or solvates thereof, are provided having the general formula I: wherein A in formula I represents the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group. R and R1 in formula I can each be a hydrogen atom or an alkyl group having one to six carbon atoms. The novel water-soluble azole compounds are useful for the treatment of fungal infections and can be administered orally, topically and parenterally.