6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS

6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS

The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT 2C receptor agonists for the treatment of 5-HT 2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R 6 is -S-L-R 15 and other subst...

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Hauptverfasser: MICHAEL JOHN RODRIGUEZ, SARAH LYNNE HELLMAN, MARIA ANGELES MARTINEZ-GRAU, DEYI ZHANG, AJAY SINGH, ANDREW CAERWYN WILLIAMS, MATTHEW ROBERT REINHARD, JOHN GORDON ALLEN, MICHAEL WADE TIDWELL, CHRISTOPHER STEPHEN SIEDEM, KARIN BRINER, WAI-MAN LEE, FRANTZ VICTOR, ROGER RYAN ROTHHAAR, CHRISTOPHER STANLEY GALKA, MICHAEL PHILIP COHEN
Format: Patent
Sprache:eng ; por
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT 2C receptor agonists for the treatment of 5-HT 2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R 6 is -S-L-R 15 and other substituents are as defined in the specification.