COMPOSITIONS AND METHODS FOR INCREASING BONE MINERALIZATION

The invention relates to an antibody, or antigen-binding fragment thereof, that binds specifically to a sclerostin polypeptide. The antibody or antigen-binding fragment is useful for increasing bone mineral content and/or bone mineral density in a warm-blooded animal or human, for example in the tre...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	JEFFREY VAN NESS, DAVID G. WINKLER, JOHN T. MULLIGAN, DAVID J. GALAS, BRYAN W. PAEPER, BRIAN KOVACEVICH, MARY E. BRUNKOW
Format:	Patent
Sprache:	eng ; por
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to an antibody, or antigen-binding fragment thereof, that binds specifically to a sclerostin polypeptide. The antibody or antigen-binding fragment is useful for increasing bone mineral content and/or bone mineral density in a warm-blooded animal or human, for example in the treatment of conditions such as osteopenia, osteoporosis, a fracture, achondroplasia, cleidrocranial dysostosis, echondromatosis, fibrous dysplasia, Gaucher's Disease, hypophoshatemic rickets, Marfan's syndrome, multiple hereditary exotoses, neurofibromatosis, osteogenesis inperfecta, osteopetrosis, osteopoikilosis, sclerotic lesions, peridontal disease, pseudoarthosis and pyogenic osteolmyelitis.