NOVEL LIGANDS THAT ARE INHIBITORS OF THE RAR RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS

Biaryl compounds (I), their salts, bases or optical isomers are new. Biaryl compounds of formula (I), their salts, bases or optical isomers are new. R1 = -CH=CH-R6, -C-triple bond-C-R6 or 2-naphthyl substituted by C(O)R5; R2 and R3 = H, 1-6C alkyl (preferably T), -OR7 or -NR8R9; R2 + R3 = 6-membered ring optionally substituted by 1-3C alkyl; R4 = aryl (preferably phenyl (optionally substituted by at least one 1-6C alkyl, alkoxy, mono- or di-alkylamino or halo) or heterocyclyl (preferably pyridine, morpholine, piperidine, piperazine or tetrahydropyridine (all optionally N-substituted by alkyl or 1-4C alkylcarbamate)); X = -CR10R11, -C(O) or C=NOR12; R5 = OH, alkoxy (preferably T1), 1-6C alkyl (preferably T), or mono- or di-alkylamino; R6 = phenyl (substituted by R14 and C(O)R13) or pyridyl(substituted by C(O)R13); R7 = benzyl (optionally substituted by 1-6C alkyl (preferably T)), H, 1-6C alkyl (preferably T), halogen (preferably F, Cl or Br), dialkylamino or alkoxy (preferably T1); R8 and R9 = H, 1-6C alkyl (preferably T) or benzyl; R10 = H or OH; R11 and R12 = H or 1-6C alkyl (preferably T); R13 = OH, alkoxy (preferably T1), monoalkylamino or dialkylamino; R14 = H, OH or amino; T = methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, pentyl or hexyl; T1 = methoxy, ethoxy, propyloxy, isopropyloxy, butyloxy, tert-butyloxy, pentyloxy or hexyloxy.