SUBSTITUTED PYRAZOLES AS P38 KINASE INHIBITORS

A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (IA), wherein R , R , R and R are as described in the specification.

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Bibliographische Detailangaben
Hauptverfasser:	SYAULAN YANG, HE HUANG, LIFENG GENG, JOHN JEFFREY TALLEY, SHAUN RAJ SELNESS, RICHARD M. WEIER, THAO D. PERRY, DANIEL L. FLYNN, SUSAN J. HARTMANN, MICHAEL S. SOUTH, MICHAEL A. STEALEY, CATHLEEN E. HANAU, FRANCIS J. KOSZYK, MICHAEL L. VAZQUEZ, RAJESH DEVRAJ, PAUL W. COLLINS, SHASHIDHAR N. RAO, YI YU, WIN NAING, MICHAEL HEPPERLE, KEVIN D. JEROME, JOYCE Z. CRICH, GUNNAR J. HANSON, XIANGDONG XU, MATTHEW J. GRANETO, JOHN K. WALKER, MICHAEL CLARE, SUZANNE METZ, RICHARD A. PARTIS, SHUYUAN LIAO, ISH K. KHANNA, ASHOK ANANTANARAYAN, JOHN E. BALDUS
Format:	Patent
Sprache:	eng ; por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (IA), wherein R , R , R and R are as described in the specification.