SUBSTITUTED 1,5-DIAMINOPENTAN-3-OL COMPOUNDS

N,N,N',N'-Tetrasubstituted 1,5-diamino-pentan-3-ol derivatives (I) are new. Diaminopentanols of formula (I), in the form of diastereomers, enantiomers or their mixtures (including racemates) and bases, salts or solvates, are new. R , R = linear or branched, saturated or unsaturated aliphat...

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Hauptverfasser: HELMUT BUSCHMANN, WERNER ENGLBERGER, BERND SUNDERMANN, HEINZ URAGG, CORINNA MAUL
Format: Patent
Sprache:eng ; por
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Zusammenfassung:N,N,N',N'-Tetrasubstituted 1,5-diamino-pentan-3-ol derivatives (I) are new. Diaminopentanols of formula (I), in the form of diastereomers, enantiomers or their mixtures (including racemates) and bases, salts or solvates, are new. R , R = linear or branched, saturated or unsaturated aliphatic residue; R +R = (CH2)n; n = 3 or more; R = linear or branched, saturated or unsaturated aliphatic residue, saturated or unsaturated cycloaliphatic residue, aryl or heteroaryl (where the ring systems are optionally substituted and optionally bonded via a linear or branched, saturated or unsaturated aliphatic bridge, the aryl or heteroaryl residues optionally being part of a polycyclic system); R , R = linear or branched, saturated or unsaturated aliphatic residue or aryl (optionally bonded via a linear or branched, saturated or unsaturated aliphatic bridge); R +R = (CH2)m; m = integer; R , R = linear or branched, saturated or unsaturated aliphatic residue or aryl (optionally bonded via a linear or branched, saturated or unsaturated aliphatic bridge); R +R = (CH2)p; p = integer; and R = H; or aryl or heteroaryl (both optionally substituted); the following compounds (I') are excluded: 1,5-bis-(N,N-dimethylamino)-2,4-dimethyl-3-pyridin-2-yl-pentan-3-ol, 2,6-bis-(N,N-dimethylaminomethyl)-1-phenylcyclohexanol, 2,6-bis-(N,N-dimethylaminomethyl)-1-pyridin-2-ylcyclohexanol and 2,7-bis-(N,N-dimethylaminomethyl)-1-pyridin-2-ylcycloheptanol. Independent claims are also included for: (1) Medicaments containing (I) or (I') as active agents, optionally together with auxiliaries; and (2) Preparation of compounds of formula (I).