DISILOXANOS SUBSTITUIDOS, METODOS PARA A SUA PRODUCAO E SUA UTILIZACAO PARA REVERTER A RESISTENCIA MULTI-DROGAS (MDR)

DISILOXANOS SUBSTITUIDOS, METODOS PARA A SUA PRODUCAO E SUA UTILIZACAO PARA REVERTER A RESISTENCIA MULTI-DROGAS (MDR)

The invention relates to novel substituted disiloxanes, the production thereof and the use thereof as biologically active compounds which greatly inhibit the efflux pump activity of malignant Mdr-tumor cells, the Pgp-resistance of parasitic cells, fungi and bacteria in the ng/ml range, do not act in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: MOLNAR, JOZSEF, KIESSIG, STEPHAN, NACSA, JANOS, SZABO, DIANA, GAAL, DEZSOE, MUCSI, ILONA, HEGYES, PETER, HEVER, ANIKO, VARGA, ANDRAS, LAGE, HERMANN
Format: Patent
Sprache:por
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to novel substituted disiloxanes, the production thereof and the use thereof as biologically active compounds which greatly inhibit the efflux pump activity of malignant Mdr-tumor cells, the Pgp-resistance of parasitic cells, fungi and bacteria in the ng/ml range, do not act in a toxic manner in vivo even in higher concentrations thereof, are immediately effective after cell substance contact and improve the efficacy of cytostatics to a considerable extent.