PROCESSO PARA A PREPARACAO DE MESILATOS DE DERIVADOS DE PIPERAZINA

PROCESSO PARA A PREPARACAO DE MESILATOS DE DERIVADOS DE PIPERAZINA

The invention relates to the mesylates of a group of piperazine derivatives and to a process for the preparation of these mesylates in an economic way in the high yield and of high purity. According to the process of the invention the synthesis of the piperazine ring and the mesylate formation are c...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SCHOUTEN, STEFANUS, J, ZORGDRAGER, JAN, AAR, MARCEL, P.M. VAN, HESLINGA, MICHIEL, C
Format: Patent
Sprache:por
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to the mesylates of a group of piperazine derivatives and to a process for the preparation of these mesylates in an economic way in the high yield and of high purity. According to the process of the invention the synthesis of the piperazine ring and the mesylate formation are combined in a single reaction step. The invention relates to the mesylate of compounds of the formula (I) wherein X is a bicyclic heterocyclic phenyl group and Y is methyl, ethyl (optionally substituted with fluorine), cycloalkyl (3-7C) methyl, benzyl or m-phenyl benzyl