HYDROGEL-DRIVEN DRUG DOSAGE FORM

A controlled -release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating arou...

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Bibliographische Detailangaben
Hauptverfasser:	DWAYNE THOMAS FRIESEN, LEAH ELIZABETH APPEL, MARK BRIAN CHIDLAW, KELLY LINCOLN SMITH, AVINASH GOVIND THOMBRE, WILLIAM JOHN CURATOLO, RONALD ARTHUR BEYERINCK
Format:	Patent
Sprache:	eng ; por
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	A controlled -release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.