PREPARATION OF QUINOLINE-SUBSTITUTED CARBONATE AND CARBAMATE DERIVATIVES

The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate th...

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Bibliographische Detailangaben
Hauptverfasser:	MICHAEL S. ALLEN, HEMANT H. PATEL, JIEN-HEH J. TIEN, STEVEN J. WITTENBERGER, JOHN J. DEMATTEI, STEPHEN CONDON, LAWRENCE KOLACZKOWSKI, DANIEL J. PLATA, RAMIYA H. PREMCHANDRAN, ERIC J. STONER, SOU-JEN CHANG, PAUL J. NICHOLS, SUBHASH R. PATEL, SUKUMAR MANNA, STEVEN A. KING
Format:	Patent
Sprache:	eng ; por
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
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Beschreibung
Zusammenfassung:	The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. R 1 -CH=CHCH 2 OC(O)-X-R 2 (I)