SOLID PHASE PEPTIDE SYNTHESIS METHOD

SOLID PHASE PEPTIDE SYNTHESIS METHOD

A procedure for the solid phase peptide synthesis (SPPS), following a linear or convergent strategy, wherein the peptides contain the sequence of general formula (I), wherein n, Y, X and A1 to An have the meanings indicated in the specification. Said procedure comprises: the use of amino acids with...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MARC CANAS I POBLET, BERTA PONSATI I OBIOLS, GEMMA JODAS I FARRES, JORDI BARCADIT I CABADO, JAVIER CLEMENTE RODRIGUEZ
Format: Patent
Sprache:eng ; por
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:A procedure for the solid phase peptide synthesis (SPPS), following a linear or convergent strategy, wherein the peptides contain the sequence of general formula (I), wherein n, Y, X and A1 to An have the meanings indicated in the specification. Said procedure comprises: the use of amino acids with the N alpha group protected, protecting the side chains of those amino acids that have their side chain alkylated or acylated in the final product with labile protecting groups, protecting the side chains of at least one of the amino acids that has its chain free in the final product with hyperlabile products and using a polymeric support which provides labile peptide-resin bonds. Said procedure is valid for the synthesis of gosereline and busereline. Y-A1-A2-A3-...-A(n-1)-An-X