Asymmetrically substituted antrapyridazone derivatives used as cytostatics modulating multidrug resistance of tumor cells

Asymmetrically substituted antrapyridazone derivatives used as cytostatics modulating multidrug resistance of tumor cells

The invention relates to the new, asymmetrically substituted derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione and their use as cytostatics exhibiting activity against tumor cells, especially against cells with multidrug resistance (MDR). In particular, the invention concerns derivative...

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Bibliographische Detailangaben
Hauptverfasser: BONTEMPS-GRACZ MARIA, WYSOCKA MALGORZATA, WIETRZYK JOANNA, MAZERSKI JAN, PUNDA PAWEL, BOROWSKI EDWARD, DZIEDUSZYCKA MARIA, STEFANSKA BARBARA, SZELEJEWSKI WIESLAW, OBUKOWICZ JANUSZ, CYBULSKI MARCIN
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to the new, asymmetrically substituted derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione and their use as cytostatics exhibiting activity against tumor cells, especially against cells with multidrug resistance (MDR). In particular, the invention concerns derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione represented by the general formula (I).