8-CHLORO-2,3-BENZODIAZEPINE DERIVATIVES

8-CHLORO-2,3-BENZODIAZEPINE DERIVATIVES

The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula -NH-R′, wherein R′ stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SZENASI GABOR, VEGH MIKLOS, SZUCS GYULA, SZABO GEZA, BARKOCZY JOZSEF, LING ISTVAN, GIGLER GABOR, KERTESZ SZABOLCS, SIMIG GYULA, HARSING LASZLO GABOR
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula -NH-R′, wherein R′ stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.