PIPERAZINE AZASPIRO DERIVAVES

PIPERAZINE AZASPIRO DERIVAVES

The present invention provides, in part, compounds of Formula I:or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: X1, X2, R1, R2, m and n are as described herein; processes for the preparation of; intermediates used in the preparation of; and compo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HELAL, CHRISTOPHER JOHN, ZHANG, LEI, KABLAOUI, NATASHA MARIAM, LACHAPELLE, ERIK ALPHIE, BUTLER, CHRISTOPHER RYAN, WEBB, DAMIEN, BRODNEY, MICHAEL AARON, MCALLISTER, LAURA ANN, YANG, QINGYI
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides, in part, compounds of Formula I:or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: X1, X2, R1, R2, m and n are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, Parkinson's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.