SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE

SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE

Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions cont...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BOEHM TERRI L, MADSEN HEATHER M, DEVADAS BALEKUDRU, WALKER JOHN, HICKORY BRIAN S, DEVRAJ RAJESH, PROMO MICHELE A, DURLEY RICHARD C, SELNESS SHAUN R, ALVIRA EDGARDO, JEROME KEVIN D, RUCKER PAUL V
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.