HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS

HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS

The compounds of Formula I, Formula Ia, and Formula Ib are described herein along with their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds inhibit PRMT5 and...

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Hauptverfasser: VADIVELU, SARAVANAN, KANAGARAJ, SUBRAMANIAM, THAKUR, MANISH KUMAR, SWAMY, INDU N, MOHD, ZAINUDDIN, BURRI, RAGHUNADHA REDDY, NAGARAJU, NAGENDRA, NATARAJAN, TAMIZHARASAN, GARAPATY, SHIVANI, SIVANANDHAN, DHANALAKSHMI, RAJAGOPAL, SRIDHARAN, SARKAR, SAYANTANI, SAMANTA, SWAPAN KUMAR, HARIPRAKASH
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The compounds of Formula I, Formula Ia, and Formula Ib are described herein along with their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds inhibit PRMT5 and are useful as therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, Parkinson's disease and the like.