AROMATIC SULFONE HYDROXAMATES AND THEIR USE AS PROTEASE INHIBITORS

AROMATIC SULFONE HYDROXAMATES AND THEIR USE AS PROTEASE INHIBITORS

This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to...

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Hauptverfasser: FOBIAN YVETTE M, WANG LIJUAN JANE, RICO JOSEPH G, KASSAB DARREN J, BARTA THOMAS E, BECKER DANIEL P, CARROLL JEFFREY N, BOEHM TERRI L, TALLEY JOHN J, VILLAMIL CLARA I, DECRESCENZO GARY A, MISCHKE DEBORAH A, HOCKERMAN SUSAN L, NORTON MONICA B, BEDELL LOUIS J, FRESKOS JOHN N, MCDONALD JOSEPH J, KOLODZIEJ STEVE A
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.