PROCESS FOR PRODUCING 4-AMINO-1-HIDROXYBUTYLIDENE-1,1-BISPHOSPHONIC ACID AND ITS TRIHYDRATED MONOSODIC SALT

PROCESS FOR PRODUCING 4-AMINO-1-HIDROXYBUTYLIDENE-1,1-BISPHOSPHONIC ACID AND ITS TRIHYDRATED MONOSODIC SALT

The invention relates to a process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid and of the trihydrated monosodium salt thereof, consisting of reacting 4-aminobutyric acid with a phosphonation mixture formed by phosphorous acid and methanesulfonic anhydride and thereafter...

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Hauptverfasser: BOSCH ILLADO JORDI, PAGANS LISTA EUGENIA, ONRUBIA MIGUEL M DEL CARMEN
Format: Patent
Sprache:eng ; pol
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ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
INFORMATION STORAGE
INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORDCARRIER AND TRANSDUCER
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
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creator BOSCH ILLADO JORDI
PAGANS LISTA EUGENIA
ONRUBIA MIGUEL M DEL CARMEN
description The invention relates to a process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid and of the trihydrated monosodium salt thereof, consisting of reacting 4-aminobutyric acid with a phosphonation mixture formed by phosphorous acid and methanesulfonic anhydride and thereafter hydrolyzing the product of said reaction and isolating the products by adjustment of the pH.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
INFORMATION STORAGE
INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORDCARRIER AND TRANSDUCER
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
title PROCESS FOR PRODUCING 4-AMINO-1-HIDROXYBUTYLIDENE-1,1-BISPHOSPHONIC ACID AND ITS TRIHYDRATED MONOSODIC SALT
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