PROCESS FOR PRODUCING 4-AMINO-1-HIDROXYBUTYLIDENE-1,1-BISPHOSPHONIC ACID AND ITS TRIHYDRATED MONOSODIC SALT

PROCESS FOR PRODUCING 4-AMINO-1-HIDROXYBUTYLIDENE-1,1-BISPHOSPHONIC ACID AND ITS TRIHYDRATED MONOSODIC SALT

The invention relates to a process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid and of the trihydrated monosodium salt thereof, consisting of reacting 4-aminobutyric acid with a phosphonation mixture formed by phosphorous acid and methanesulfonic anhydride and thereafter...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BOSCH ILLADO JORDI, PAGANS LISTA EUGENIA, ONRUBIA MIGUEL M DEL CARMEN
Format: Patent
Sprache:eng ; pol
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
INFORMATION STORAGE
INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORDCARRIER AND TRANSDUCER
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
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Beschreibung
Zusammenfassung:The invention relates to a process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid and of the trihydrated monosodium salt thereof, consisting of reacting 4-aminobutyric acid with a phosphonation mixture formed by phosphorous acid and methanesulfonic anhydride and thereafter hydrolyzing the product of said reaction and isolating the products by adjustment of the pH.