POLYMORPHS OF CRYSTALLINE (2-BENZHYDRYL-1-AZABICYCLO[2,2,2]OCT-3-YL)-(5-ISOPROPYL-2-METHOXYBENZYL)-AMMONIUMCHLORIDE AS NK-1 RECEPTOR ANTAGONISTS

Two crystalline polymorphic forms of (2-Benzhydryl-1-azo-bicyclo(2.2.2]Octyl-3-yl)-(5-iso-propyl-2-methoxybenzyl)amine dihydrochloride dihydrate are Form I and Form II. The pharmaceutical composition containing at least are of these polymorphs has advantageous stability for formulation to treat emes...

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Hauptverfasser:	APPLETON TROY ANTHONY, NORRIS TIMOTHY, MUEHLBAUER DAVID JOSEPH, GUMKOWSKI MICHAEL JON, ALLEN DOUGLAS JOHN MELDRUM
Format:	Patent
Sprache:	eng ; pol
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Two crystalline polymorphic forms of (2-Benzhydryl-1-azo-bicyclo(2.2.2]Octyl-3-yl)-(5-iso-propyl-2-methoxybenzyl)amine dihydrochloride dihydrate are Form I and Form II. The pharmaceutical composition containing at least are of these polymorphs has advantageous stability for formulation to treat emesis in patients receiving chemotherapy. The administration of this pharmaceutical composition is conventional oral by preferably tablet or capsule or intravenous. A method of making Forms I and II is also disclosed.