METHOD FOR THE SYNTHESIS OF PENTOSTATIN

The present invention relates to a method for the stereo-selective production of pentostatin comprising an enzymatic transglycosylation reaction between an imidazo-[4,5- d ]-[1,3]diazepine compound and a 2'-deoxyribonucleotide, followed by an ruthenium-catalyzed asymmetric transfer hydrogenatio...

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Bibliographische Detailangaben
Hauptverfasser:	SYPCHENKO, VOLODYMYR, ZABUDKIN, OLEKSANDR, SCHICKANEDER, CHRISTIAN, MATVIIENKO, IAROSLAV
Format:	Patent
Sprache:	eng ; pol
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a method for the stereo-selective production of pentostatin comprising an enzymatic transglycosylation reaction between an imidazo-[4,5- d ]-[1,3]diazepine compound and a 2'-deoxyribonucleotide, followed by an ruthenium-catalyzed asymmetric transfer hydrogenation.