CARRIER FOR TARGETING NERVE CELLS

New transport protein (A) obtained by modification of the heavy chain of a neurotoxin produced by Clostridium botulinum. Compared with the native neurotoxin (nNT) it: (a) binds with higher or lower affinity to nerve cells; (b) has higher/lower neurotoxicity, particularly as determined in the hemidia...

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Bibliographische Detailangaben
Hauptverfasser:	GUTCAITS, ALEKSANDRS, WEIL, TANJA, RUMMEL, ANDREAS
Format:	Patent
Sprache:	eng ; pol
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	New transport protein (A) obtained by modification of the heavy chain of a neurotoxin produced by Clostridium botulinum. Compared with the native neurotoxin (nNT) it: (a) binds with higher or lower affinity to nerve cells; (b) has higher/lower neurotoxicity, particularly as determined in the hemidiaphragm assay; and/or (c) has lower affinity for neutralizing antibodies. Independent claims are also included for the following: (1) composition (C) comprising (A) and at least one intervening compound; (2) method for producing (A) or (C) by standard recombinant methods; (3) host cells that contain a recombinant expression vector (EV) encoding (A) or (C); and (4) EV. ACTIVITY : Relaxant; Antimigraine; Analgesic; Vulnerary; Antidepressant; Virucide. No details of tests for these activities are given. MECHANISM OF ACTION : Delivering agents that inhibit release of neurotransmitters.