SIRP-ALPHA VARIANT CONSTRUCTS AND USES THEREOF

The invention relates to compositions and methods of SIRP-α variant constructs including SIRP-α variants. The SIRP-α variant constructs may be engineered in a variety of ways to respond to environmental factors, such as pH, hypoxia, and/or the presence of tumor-associated enzymes or tumor-associated...

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Bibliographische Detailangaben
Hauptverfasser:	SIM, BANG JANET, GOODMAN, COREY, PONS, JAUME, VRLJIC, MARIJA, DEMING, LAURA
Format:	Patent
Sprache:	eng ; pol
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to compositions and methods of SIRP-α variant constructs including SIRP-α variants. The SIRP-α variant constructs may be engineered in a variety of ways to respond to environmental factors, such as pH, hypoxia, and/or the presence of tumor-associated enzymes or tumor-associated antigens. The SIRP-α variant constructs of the invention may be used to treat various diseases, such as cancer, preferably solid tumor or hematological cancer.