BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Inte...
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| creator | BUNNAGE, MARK EDWARD LOWE, MICHAEL DENNIS LEE, ARTHUR LOVERING, FRANK ELDRIDGE PATNY, AKSHAY SAIAH, EDDINE PAPAIOANNOU, NIKOLAOS ZAPF, CHRISTOPH WOLFGANG LEE, KATHERINE LIN PIERCE, BETSY SUSAN VARGAS, RICHARD TRZUPEK, JOHN DAVID GOLDBERG, JOEL ADAM HAN, SEUNGIL HUANG, HORNGIH HEPWORTH, DAVID MATHIAS, JOHN PAUL WANG, XIAOLUN ANDERSON, DAVID RANDOLPH STROHBACH, JOSEPH WALTER GAVRIN, LORI KRIM WRIGHT, STEPHEN WAYNE CURRAN, KEVIN JOSEPH DEHNHARDT, CHRISTOPH MARTIN |
| description | Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Interleukin-1 Receptor Associated Kinase (IRAK), methods of synthesis, and intermediates are also disclosed. |
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Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Interleukin-1 Receptor Associated Kinase (IRAK), methods of synthesis, and intermediates are also disclosed.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS |
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