BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS

BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Inte...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: BUNNAGE, MARK EDWARD, LOWE, MICHAEL DENNIS, LEE, ARTHUR, LOVERING, FRANK ELDRIDGE, PATNY, AKSHAY, SAIAH, EDDINE, PAPAIOANNOU, NIKOLAOS, ZAPF, CHRISTOPH WOLFGANG, LEE, KATHERINE LIN, PIERCE, BETSY SUSAN, VARGAS, RICHARD, TRZUPEK, JOHN DAVID, GOLDBERG, JOEL ADAM, HAN, SEUNGIL, HUANG, HORNGIH, HEPWORTH, DAVID, MATHIAS, JOHN PAUL, WANG, XIAOLUN, ANDERSON, DAVID RANDOLPH, STROHBACH, JOSEPH WALTER, GAVRIN, LORI KRIM, WRIGHT, STEPHEN WAYNE, CURRAN, KEVIN JOSEPH, DEHNHARDT, CHRISTOPH MARTIN
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Interleukin-1 Receptor Associated Kinase (IRAK), methods of synthesis, and intermediates are also disclosed.