PROCESS FOR PREPARING 3'-THIOSUBSTITUTED CEPHALOSPORINS EMPLOYING A PENICILLIN G ACYLASE

The present invention relates to a process for the preparation of 3′-thiosubstituted cephalosporins by enzymatic condensation of a nucleus with a phenylglycine derivative. Furthermore the present invention relates to a crystalline form of a compound of general formula (1) wherein R2 is OH and X is S...

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Bibliographische Detailangaben
Hauptverfasser: MOODY, HAROLD MONRO, CUSAN, CLAUDIA, IJPEIJ, EDWIN GERARD
Format: Patent
Sprache:eng ; pol
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Beschreibung
Zusammenfassung:The present invention relates to a process for the preparation of 3′-thiosubstituted cephalosporins by enzymatic condensation of a nucleus with a phenylglycine derivative. Furthermore the present invention relates to a crystalline form of a compound of general formula (1) wherein R2 is OH and X is S and R1 is a radical of formula (2a) with R3 is CH3.