A PROCESS FOR PREPARATION OF INSULIN COMPOUNDS

A PROCESS FOR PREPARATION OF INSULIN COMPOUNDS

The present invention relates to the preparation of insulin compounds including their analogs or derivatives thereof from their corresponding precursor forms by a one step enzymatic reaction involving the combinatorial and concurrent use of optimal quantities of trypsin and carboxypeptidase B that w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHIVARUDRAIAH MANJUNATH HADAVANAHALLI, HAZRA PARTHA, SATHYANARAYANA SRIKANTH GOLLARAHOSAHALLI, SASTRY KEDARNATH NANJUND, SREENIVAS SUMA, IYER HARISH
Format: Patent
Sprache:eng ; pol
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to the preparation of insulin compounds including their analogs or derivatives thereof from their corresponding precursor forms by a one step enzymatic reaction involving the combinatorial and concurrent use of optimal quantities of trypsin and carboxypeptidase B that work synergistically directing the reaction in a controlled manner to avoid production of random undesired byproducts. Particularly, the enzymatic conversion reactions of the instant invention offer advantages of reduction in the number operational steps, higher yield and purity of the desired end products.