Application of composition containing monomeric calicheamicin derivative/anti-CD22 antibody conjugates

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the...

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Hauptverfasser:	KUNZ ARTHUR, MERCHANT NISHITH, RUBINO JOSEPH THOMAS, SIMPSON JOHN MCLEAN, POPPLEWELL ANDREW GEORGE, JAIN NEERA, ROBBINS PAUL DAVID, MORAN JUSTIN KEITH, VIDUNAS EUGENE JOSEPH, RUPPEN MARK EDWARD, DAMLE NITIN KRISHNAJI, DIJOSEPH JOHN FRANCIS
Format:	Patent
Sprache:	eng ; pol
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.