METHOD FOR REDUCING AMYLOID DEPOSITION, AMYLOID NEUROTOXICITY, AND MICROGLIOSIS WITH (-)-NILVADIPINE ENANTIOMER

METHOD FOR REDUCING AMYLOID DEPOSITION, AMYLOID NEUROTOXICITY, AND MICROGLIOSIS WITH (-)-NILVADIPINE ENANTIOMER

The present invention provides methods for reducing A deposition, A neurotoxicity and microgliosis in an animal or human afflicted with a cerebral amyloidogenic disease, such as Alzheimer's disease (AD), by administering therapeutically effective amounts of the (R)-enantiomer of the dihydropyri...

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Hauptverfasser: MULLAN, MICHAEL J, IVEY, ROBERT A. III, PARIS, DANIEL
Format: Patent
Sprache:eng ; pol
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator MULLAN, MICHAEL J
IVEY, ROBERT A. III
PARIS, DANIEL
description The present invention provides methods for reducing A deposition, A neurotoxicity and microgliosis in an animal or human afflicted with a cerebral amyloidogenic disease, such as Alzheimer's disease (AD), by administering therapeutically effective amounts of the (R)-enantiomer of the dihydropyridine compound nilvadipine, also known as (−)-nilvadipine, to the animal or human. Further provided are methods for reducing the risk of A deposition, A neurotoxicity and microgliosis in animals or humans suffering from traumatic brain injury by administering (−)-nilvadipine after the traumatic brain injury and continuing treatment for a prescribed period of time thereafter.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title METHOD FOR REDUCING AMYLOID DEPOSITION, AMYLOID NEUROTOXICITY, AND MICROGLIOSIS WITH (-)-NILVADIPINE ENANTIOMER
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