METHOD FOR REDUCING AMYLOID DEPOSITION, AMYLOID NEUROTOXICITY, AND MICROGLIOSIS WITH (-)-NILVADIPINE ENANTIOMER

METHOD FOR REDUCING AMYLOID DEPOSITION, AMYLOID NEUROTOXICITY, AND MICROGLIOSIS WITH (-)-NILVADIPINE ENANTIOMER

The present invention provides methods for reducing A deposition, A neurotoxicity and microgliosis in an animal or human afflicted with a cerebral amyloidogenic disease, such as Alzheimer's disease (AD), by administering therapeutically effective amounts of the (R)-enantiomer of the dihydropyri...

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Bibliographische Detailangaben
Hauptverfasser: MULLAN, MICHAEL J, IVEY, ROBERT A. III, PARIS, DANIEL
Format: Patent
Sprache:eng ; pol
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides methods for reducing A deposition, A neurotoxicity and microgliosis in an animal or human afflicted with a cerebral amyloidogenic disease, such as Alzheimer's disease (AD), by administering therapeutically effective amounts of the (R)-enantiomer of the dihydropyridine compound nilvadipine, also known as (−)-nilvadipine, to the animal or human. Further provided are methods for reducing the risk of A deposition, A neurotoxicity and microgliosis in animals or humans suffering from traumatic brain injury by administering (−)-nilvadipine after the traumatic brain injury and continuing treatment for a prescribed period of time thereafter.