(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-PIPERAZINES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATION

(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-PIPERAZINES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATION

Inhibitors of LIM kinase 2 of the following formula are disclosed, along with pharmaceutical compositions comprising them and methods of their use, in particular for treatment of inflammatory and cancerous and ocular diseases. X is O or NR A ; A is cycloalkyl, aryl or heterocyclyl; R A is hydrogen,...

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Bibliographische Detailangaben
Hauptverfasser: MABON, ROSS, RAWLINS, DAVID BRENT, HARRISON, BRYCE ALDEN, RICE, DENNIS S, KIMBALL, SPENCER DAVID, VORONKOV, MICHAEL VICTOR, ZHANG, YULIAN
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Inhibitors of LIM kinase 2 of the following formula are disclosed, along with pharmaceutical compositions comprising them and methods of their use, in particular for treatment of inflammatory and cancerous and ocular diseases. X is O or NR A ; A is cycloalkyl, aryl or heterocyclyl; R A is hydrogen, cyano, nitro, RA 1 , SO 2 RA 1 or SO 2 N(RA 1 ) 2 ; each R B is independently hydrogen or alkyl. The other variables are as defined in the claims.