1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS

The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor. wherein A is C, CR 10 or N; X is N; Y is CR 7 ; R 1 is H, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkoxycarbonyl or a C 1 -C 6 alkyl, C 2 -C 6 a...

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Hauptverfasser: KELLY MICHAEL GERARD, COLE DEREK CECIL
Format: Patent
Sprache:eng ; pol
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Zusammenfassung:The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor. wherein A is C, CR 10 or N; X is N; Y is CR 7 ; R 1 is H, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkoxycarbonyl or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or cycloheteroalkyl group each optionally substituted; R 2 , R 3 , R 4 , R 5 and R 6 are each independently H, halogen, OH or an optionally substituted C 1 -C 6 alkyl group; R 7 is H, halogen or a C 1 -C 6 alkyl, aryl, heteroaryl or C 1 -C 6 alkoxy group each optionally substituted; R 8 is a C 1 -C 6 alkyl, aryl or heteroaryl group each optionally substituted; R 9 is H, halogen or a C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, aryl or heteroaryl group each optionally substituted; R 10 is H, OH or an optionally substituted C 1 -C 6 alkoxy group; m is an integer of 1, 2 or 3; n is 0 or an integer of 1, 2 or 3; and --- represents a single bond or a double bond; or a pharmaceutically acceptable salt thereof.