PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1ALPHA,3ALPHA,4BETA)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE

PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1ALPHA,3ALPHA,4BETA)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE

The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophob...

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Bibliographische Detailangaben
Hauptverfasser: VEMISHETTI PURUSHOTHAM, KUCERA DAVID J, PRASAD SIVA JOSYULA, PATEL SUNIL S, SHI ZHONGPING, LIANG JING, RIJHWANI SUSHIL K, SINGH AMBARISH K, BIEN JEFFREY T, LEWIS CHARLES, POLNIASZEK RICHARD, ZHOU MAOTANG X, BANERJEE AMIT, CHEN CHUNG-PIN H, PATEL RAMESH N, STOJANOVIC MILAN, PENDRI YADAGIRI R, WANG SHAOPENG, EVANS JEFFREY M, KRONENTHAL DAVID R, CHAN YEUNG Y, POWERS GERALD L, THOTTATHIL JOHN K, KRISHNAMURTY DHILEEPKUMAR
Format: Patent
Sprache:eng ; pol
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophobic resin bed; (b) washing the resin bed with water to remove salt; and (c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.