METHOD FOR THE SYNTHESIS OF N- [3- [ (2-METHOXYPHENYL) SULFANYL] -2- METHYLPROPYL]-3,4-DIHYDRO-2H-1,5-BENZOXATHIEPIN-3-AMINE

METHOD FOR THE SYNTHESIS OF N- [3- [ (2-METHOXYPHENYL) SULFANYL] -2- METHYLPROPYL]-3,4-DIHYDRO-2H-1,5-BENZOXATHIEPIN-3-AMINE

Preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine (I) comprises condensation of 7,8-dihydro-6H-5-oxa-9-thia-benzocyclohepten-7-ylamine compound (II) and 5-methoxy-6-(2-methyl-butylsulfanyl)-cyclohexa-1,3-diene compound (III). Preparation of N-[...

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Bibliographische Detailangaben
Hauptverfasser: BRUNEL, YVES, MAUREL, JEAN-LOUIS, VACHER, BERNARD
Format: Patent
Sprache:eng ; pol
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine (I) comprises condensation of 7,8-dihydro-6H-5-oxa-9-thia-benzocyclohepten-7-ylamine compound (II) and 5-methoxy-6-(2-methyl-butylsulfanyl)-cyclohexa-1,3-diene compound (III). Preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine (I) comprises condensation of intermediate of 7,8-dihydro-6H-5-oxa-9-thia-benzocyclohepten-7-ylamine compound (II) and 5-methoxy-6-(2-methyl-butylsulfanyl)-cyclohexa-1,3-diene compound of formula (III). R : methyl group, preferably 4-methylphenyl. An independent claim is included for the new intermediate compound (III). [Image] ACTIVITY : Antianginal; Cardiant. MECHANISM OF ACTION : None given. No biological data given.