PURIFICATION PROCESS OF MONTELUKAST AND ITS AMINE SALTS

PURIFICATION PROCESS OF MONTELUKAST AND ITS AMINE SALTS

It comprises a process for the purification of Montelukast, or its salts or its solvates, including any stereoisomer or mixture thereof, which comprises converting Montelukast acid or a solvate thereof, including any stereoisomer or mixtures thereof, into an amine salt selected from the group consis...

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Bibliographische Detailangaben
Hauptverfasser: MONSALVATJE LLAGOSTERA, MONTSERRAT, TALAVERA ESCASANY, PEDRO, GASANZ GUILLEN, YOLANDA
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:It comprises a process for the purification of Montelukast, or its salts or its solvates, including any stereoisomer or mixture thereof, which comprises converting Montelukast acid or a solvate thereof, including any stereoisomer or mixtures thereof, into an amine salt selected from the group consisting of cyclohexylamine, tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3-propanediol, R-(+)-±-methylbenzylamine, and L-(+)-±-phenylglycinol salt, in the presence of an appropriate solvent. It also comprises novel salts of Montelukast, in particular, cyclohexylamine, tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3-propanediol, R-(+)-±-methylbenzylamine, and L-(+)-±-phenylglycinol salts.