Tetrahydropyranoquinoline derivatives

2-(Hetero)aryl-substituted 1,2,3,4-tetrahydroquinoline and 1,2,3,4-tetrahydro-1,5-naphthyridine derivatives (I) (including tricyclic analogs, e.g. pyrano-quinolines), are new. 2-(Hetero)aryl-substituted 1,2,3,4-tetrahydroquinoline and 1,2,3,4-tetrahydro-1,5-naphthyridine derivatives of formula (I) and their derivatives, solvates, tautomers, salts and stereoisomers (including mixtures in all proportions) are new. W = CH or N; R 1> - R 3> = H, R, A, Ar, halo, (CY 2) n-Q 1>, cycloalkyl, SMe, SCN, CF 3, OCF 3, OA, SCF 3, SF 5, SiMe 3, CO-(CY 2) n-Me, CH(CH 2) n-Q 2>, NCO, NCOOR, N(CH 2) nOH, CHNH 2, C(OH)R, CHNCOR, N(CH 2) nCOOR, N(CH 2) nCONR 2, XCONR(CH 2) nNR 2, N((CH 2) nXCOOR)-CO(CH 2) nAr, N((CH 2) nXR)-Q 3>, N((CH 2) nNRCOOR)CO(CH 2) nAr, N((CH 2) nNR 2)-Q 4>, O(CH 2) nNR 2, X(CH 2) nNR 2 or NCO(CH 2) nNR 2, or R 1> + R 2> = -N-C(CF 3)=N-, -N-CR=N- or -N-N=N-; Q 1> = SA, SCF 3, SCN, CF 3, OCF 3, OH, COOR, CN, halo, NR 2, OA, OCOA, CONR 2, NHCOA, NHSO 2A or N-pyrrolidone; Q 2> = NRCOOR, COOR, OH, NR 2, Ar, R 1> or X(CH 2) nAr; Q 3> = CO(CH 2) nAr, CO(CH 2) nXAr or SO 2(CH 2) nAr; Q 4> = CO(CH 2) nAr, CO(CH 2) nNRAr or SO 2(CH 2) nAr; Ar = aryl or heteroaryl; Y = H, A or halo; A = alkyl or cycloalkyl (both os by one or more halo); R = H or A, or geminal groups R = (CH 2) 5, (CH 2) 4, (CH 2) 2X(CH 2) 2 or (CH 2) 2Z(CH 2) 2; (MK#12) R 4>, R 5> = H, N-pyrrolidone residue (optionally substituted by one or more of OR, NO 2, halo, CF 3, OCF 3, CN, NR 2, SR or Ar), -X(CH 2) 2OR, -XCO(CH 2) nMe, -X(CH 2) 2NR 2, R 1>, arylthio, aryloxy or CH 2SiMe 3, or R 4> + R 5> = X(CR 2) 2, X(CR 2) 3, X(CHCH 2OR)(CH 2) 2, X(CHCH 2NR 2)(CH 2) 2, X(CH 2) 2NR 2, (CR 2) 3, X(CR 2) 4, CR=CR-CR=CR, XCHQ(CR 2) 2, XCHQCR 2, R-N-(C=X)-N-R or XC((CH 2) nOR) 2CH 2CH 2; X = O, S or NR; Q = halomethyl, CHO, COR a>, CH 2R a>, CH 2OCOR a>, CH 2NCOR 1>, CH 2N(R 1>) 2, CH 2OR 1>, CH 2OCON(R 1>) 2, CH 2OCOOR 1>, CH 2NHCON(R 1>) 2 or -CH 2NHCOOR 1>; R a> = -(CH 2) n-(X(CH 2) n) m-Q 5>, 4-(CH 2CH(CONH 2)-COO-(CH 2) nQ 6>)-1H-imidazol-1-yl, 2-oxa-3-oxo-4,7,7-tri-(R)-bicyclo-(2,2,1)-heptan-ylcarbonyloxy, OR, NHR 2, NR 2, NR(CH 2) n-aryl, NR(CH 2) n-OR, COOR, N-pyrrolidone, OCOR, NR(CH 2) n-NR 2, N((CH 2) nNR 2)CO(CH 2) nQ 7>, N((CH 2) nNHCOOR)-CO-aryl, R 1>, N(CH 2(CH 2) nOR) 2, NR(CH 2) nNCOOR, X(CH 2) nX(CH 2) nXR, X(CH 2) nX(CH 2) nOH, NR(CH 2) nO(CH 2) nOH, (CH 2) nCOOR, OCONR(CH 2) nOR, OCONR(CH 2) nNR 2, NR(CH 2) nNR 2, N((CH 2) nXR)CO(CH 2) nAr, N(R)(CH2) nN(R)COOR, XCOO(CH 2) nNR 2, OSO 2A,