IMPROVED PROCESS FOR PREPARING NITROGEN−SUBSTITUTED AMINOTETRALINS

IMPROVED PROCESS FOR PREPARING NITROGEN−SUBSTITUTED AMINOTETRALINS

The present invention relates to a process for preparing optically active and racemic nitrogen-substituted 2-aminotetralins of the following Formula (I):wherein R1, R2, R3, R4, and n are set in the specification, wherein the process comprises alkylating the corresponding unsubstituted 2-aminotetrali...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RIPPEL KEITH, MINASKANIAN GEVORK
Format: Patent
Sprache:eng ; pol
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a process for preparing optically active and racemic nitrogen-substituted 2-aminotetralins of the following Formula (I):wherein R1, R2, R3, R4, and n are set in the specification, wherein the process comprises alkylating the corresponding unsubstituted 2-aminotetralin of Formula (II):with a reactant of the Formula (III):wherein Z is a leaving group, in the presence of a base, wherein the base is selected from the group consisting of alkali metal carbonate and alkali metal bicarbonate, and wherein the amount of the base is less than about a 1.9-fold molar excess with respect to the amount of the 2-aminotetralin.