Derivatives of amides, method of obtaining them and pharmaceutic compositions containing such derivatives

Compounds of the formula: wherein: n is 0, 1 or 2; Y is hydroxy or XONH-, where X is hydrogen or lower alkyl; R is hydrogen or lower alkyl; R is hydrogen, lower alkyl, heteroalkyl, aryl, aralkyl, arylheteroalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heteroarylheteroalkyl, heterocyclo, heterocylo-lower alkyl, heterocyclo-lower heteroalkyl or -NR R , wherein: R is hydrogen, lower alkyl, cycloalkyl or cycloalkylalkyl, aryl, heteroaryl and heteroaralkyl; R is hydrogen, lower alkyl, cycloalkyl or cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, -C(O)R , -C(O)NR R , -SO2NR R , -SO2R , aryloxycarbonyl, or alkoxycarbonyl; or R and R together with the nitrogen atom to which they are attached represent a heterocyclo group; wherein R and R are independently hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or heteroalkyl; and R is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heteroalkyl or heterocyclo; or R and R together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclo group; R is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heteroalkyl or lower alkoxy; R is hydrogen, lower alkyl, cycloalkyl or cycloalkylalkyl; or R and R together with the carbons to which they are attached represent a cycloalkyl or heterocyclo group; or R and R together with the carbon to which they are attached represent a cycloalkyl or heterocyclo group; and R is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; or pharmaceutically acceptable salts or esters thereof exhibit useful pharmacological properties, in particular for use as matrix metalloprotease inhibitors, particularly for interstitial collagenases.