SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS
New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine k...
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| creator | RAMURTHY, SAVITHRI SHAFER, CYNTHIA SUBRAMANIAN, SHARADHA PICK, TERESA E AMIRI, PAYMAN POON, DANIEL J STUART, DARRIN AIKAWA, MINA E DOVE, JEFFREY H MCBRIDE, CHRISTOPHER LEVINE, BARRY HASKELL RENHOWE, PAUL A |
| description | New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer. |
| format | Patent |
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In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.</description><language>eng ; pol</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120229&DB=EPODOC&CC=PL&NR=1926722T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120229&DB=EPODOC&CC=PL&NR=1926722T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RAMURTHY, SAVITHRI</creatorcontrib><creatorcontrib>SHAFER, CYNTHIA</creatorcontrib><creatorcontrib>SUBRAMANIAN, SHARADHA</creatorcontrib><creatorcontrib>PICK, TERESA E</creatorcontrib><creatorcontrib>AMIRI, PAYMAN</creatorcontrib><creatorcontrib>POON, DANIEL J</creatorcontrib><creatorcontrib>STUART, DARRIN</creatorcontrib><creatorcontrib>AIKAWA, MINA E</creatorcontrib><creatorcontrib>DOVE, JEFFREY H</creatorcontrib><creatorcontrib>MCBRIDE, CHRISTOPHER</creatorcontrib><creatorcontrib>LEVINE, BARRY HASKELL</creatorcontrib><creatorcontrib>RENHOWE, PAUL A</creatorcontrib><title>SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS</title><description>New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. 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In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS |
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