SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS

SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS

New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine k...

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Hauptverfasser: RAMURTHY, SAVITHRI, SHAFER, CYNTHIA, SUBRAMANIAN, SHARADHA, PICK, TERESA E, AMIRI, PAYMAN, POON, DANIEL J, STUART, DARRIN, AIKAWA, MINA E, DOVE, JEFFREY H, MCBRIDE, CHRISTOPHER, LEVINE, BARRY HASKELL, RENHOWE, PAUL A
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.