METHOD FOR SOLUBILIZING METRONIDAZOLE

Solubilizing metronidazole comprises mixing an aqueous phase of metronidazole with glycolic niacinamide or its salts and at least two glycolic co-solvents, in the absence of cyclodextrin. Independent claims included for: (1) an aqueous metronidazole solution and obtained by the process; (2) an aqueo...

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Bibliographische Detailangaben
Hauptverfasser: MALLARD, CLAIRE, BRZOKEWICZ, ALAIN
Format: Patent
Sprache:eng ; pol
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Beschreibung
Zusammenfassung:Solubilizing metronidazole comprises mixing an aqueous phase of metronidazole with glycolic niacinamide or its salts and at least two glycolic co-solvents, in the absence of cyclodextrin. Independent claims included for: (1) an aqueous metronidazole solution and obtained by the process; (2) an aqueous solution of metronidazole and niacinamide obtained by the process comprising at least two glycolic co-solvents; and (3) a pharmaceutical composition comprising the solution. ACTIVITY : Dermatological. MECHANISM OF ACTION : None given.