INCLUSIVE COMPLEXES OF ARYLHETEROCYCLIC COMPOUND SALTS

Compositions of matter comprising a phamaceutically acceptable salt of an arylheterocyclic compound, such as ziprasidone, in a cyclodextrin. Preferred cyclodextrins are SBECD and HPBCD. The composition can comprise a dry mixture, a dry inclusion complex or an aqueous solution. The salt/cyclodextrin...

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Bibliographische Detailangaben
Hauptverfasser: KIM YESOOK, JOHNSON KEVIN CHARLES, SHANKER RAVI MYSORE
Format: Patent
Sprache:eng ; pol
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Zusammenfassung:Compositions of matter comprising a phamaceutically acceptable salt of an arylheterocyclic compound, such as ziprasidone, in a cyclodextrin. Preferred cyclodextrins are SBECD and HPBCD. The composition can comprise a dry mixture, a dry inclusion complex or an aqueous solution. The salt/cyclodextrin inclusion complex preferably provides an amount of ziprasidone of at least 2.5 mgA/ml when the complex is dissolved in water at 40% w/v. A variety of ziprasidone salts are preferred, including the mesylate, esylate, besylate, tartrate, napsylate, and tosylate.