METHOD OF OBTAINING 7-AMINODESACETYLOXYCEPHALOSPORANIC ACID (7-ADCA) BY MAKING USE OF EXPANDASE ACTIVITY IN RESPECT TO PENICILIN G

PCT No. PCT/EP96/02434 Sec. 371 Date Feb. 18, 1998 Sec. 102(e) Date Feb. 18, 1998 PCT Filed Jun. 3, 1996 PCT Pub. No. WO96/38580 PCT Pub. Date Dec. 5, 1996A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on p...

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Hauptverfasser: SCHIPPER DIRK, KOEKMAN BERTUS P, BOVENBERG ROELOF A. L, VOLLEBREGT ADRIANUS W. H
Format: Patent
Sprache:eng ; pol
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Zusammenfassung:PCT No. PCT/EP96/02434 Sec. 371 Date Feb. 18, 1998 Sec. 102(e) Date Feb. 18, 1998 PCT Filed Jun. 3, 1996 PCT Pub. No. WO96/38580 PCT Pub. Date Dec. 5, 1996A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.