CHIRAL HEPTYNE DERIVATIVES FOR THE PREPARATION OF EPOTHILONES AND PROCESSES FOR THEIR PREPARATION

The invention relates to a new synthetic process for the production of key intermediates useful in the synthesis of epothilones or epothilone derivatives, to certain compounds used to produce these key intermediates and to a process to produce said compounds. The intermediates used are represented b...

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Bibliographische Detailangaben
Hauptverfasser: SKUBALLA, WERNER, GRASKE, KLAUS-DIETER, WILLUHN, MARC, PETROV, ORLIN, PLATZEK, JOHANNES
Format: Patent
Sprache:eng ; pol
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Beschreibung
Zusammenfassung:The invention relates to a new synthetic process for the production of key intermediates useful in the synthesis of epothilones or epothilone derivatives, to certain compounds used to produce these key intermediates and to a process to produce said compounds. The intermediates used are represented by formulae II and III, wherein R is selected from H, alkyl and substituded alkyl and X1 is an oxygen protecting group.