SUBSTITUTED DERIVATIVES OF AZOLONE FOR USE IN TREATING DISEASES CAUSED BY HELIOBACTER
PCT No. PCT/EP94/00380 Sec. 371 Date Jul. 18, 1995 Sec. 102(e) Date Jul. 18, 1995 PCT Filed Feb. 9, 1994 PCT Pub. No. WO94/18978 PCT Pub. Date Sep. 1, 1994The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula (I) a pharmaceutically acceptable...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; pol |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | VAN DER EYCKEN LUC A. L ODDS FRANK C STOKBROEKX RAYMOND A HEERES JAN VAN DER AA MARCEL J. M MOSTMANS JOSEPH H |
| description | PCT No. PCT/EP94/00380 Sec. 371 Date Jul. 18, 1995 Sec. 102(e) Date Jul. 18, 1995 PCT Filed Feb. 9, 1994 PCT Pub. No. WO94/18978 PCT Pub. Date Sep. 1, 1994The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula (I) a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein X and Y each independently are CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; Z is C=O or CHOH; and Ar is phenyl optionally substituted with up to three substituents selected from hydroxy, C1-4alkyl, C1-4alkyloxy, halo, trifluoromethyl, triC1-4alkylsilyloxy, nitro, amino and cyano or pyridinyl substituted with hydroxy or C1-4alkyloxy; and -A- is a radical of formula (a-1) (a-2) (a-3) (a-4) (a-5) (a-6) or (a-7) |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_PL174836BB1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>PL174836BB1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_PL174836BB13</originalsourceid><addsrcrecordid>eNqNyr0KwjAUQOEsDqK-w30Bh1JR1_zc2EBIJPemUJdSJE6ihfr-mMEHcDrDd9YiU1bEjjOjAYPJ9ZJdjwTRgrxFHwOCjQkyIbgAnLB6uIBxhJLqp2UlA2qADr2LSmrGtBWrx_Rcyu7XjQCLrLt9md9jWebpXl7lM159czqc26NSTfvH8gUglTBR</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SUBSTITUTED DERIVATIVES OF AZOLONE FOR USE IN TREATING DISEASES CAUSED BY HELIOBACTER</title><source>esp@cenet</source><creator>VAN DER EYCKEN LUC A. L ; ODDS FRANK C ; STOKBROEKX RAYMOND A ; HEERES JAN ; VAN DER AA MARCEL J. M ; MOSTMANS JOSEPH H</creator><creatorcontrib>VAN DER EYCKEN LUC A. L ; ODDS FRANK C ; STOKBROEKX RAYMOND A ; HEERES JAN ; VAN DER AA MARCEL J. M ; MOSTMANS JOSEPH H</creatorcontrib><description>PCT No. PCT/EP94/00380 Sec. 371 Date Jul. 18, 1995 Sec. 102(e) Date Jul. 18, 1995 PCT Filed Feb. 9, 1994 PCT Pub. No. WO94/18978 PCT Pub. Date Sep. 1, 1994The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula (I) a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein X and Y each independently are CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; Z is C=O or CHOH; and Ar is phenyl optionally substituted with up to three substituents selected from hydroxy, C1-4alkyl, C1-4alkyloxy, halo, trifluoromethyl, triC1-4alkylsilyloxy, nitro, amino and cyano or pyridinyl substituted with hydroxy or C1-4alkyloxy; and -A- is a radical of formula (a-1) (a-2) (a-3) (a-4) (a-5) (a-6) or (a-7)</description><edition>6</edition><language>eng ; pol</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980930&DB=EPODOC&CC=PL&NR=174836B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980930&DB=EPODOC&CC=PL&NR=174836B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VAN DER EYCKEN LUC A. L</creatorcontrib><creatorcontrib>ODDS FRANK C</creatorcontrib><creatorcontrib>STOKBROEKX RAYMOND A</creatorcontrib><creatorcontrib>HEERES JAN</creatorcontrib><creatorcontrib>VAN DER AA MARCEL J. M</creatorcontrib><creatorcontrib>MOSTMANS JOSEPH H</creatorcontrib><title>SUBSTITUTED DERIVATIVES OF AZOLONE FOR USE IN TREATING DISEASES CAUSED BY HELIOBACTER</title><description>PCT No. PCT/EP94/00380 Sec. 371 Date Jul. 18, 1995 Sec. 102(e) Date Jul. 18, 1995 PCT Filed Feb. 9, 1994 PCT Pub. No. WO94/18978 PCT Pub. Date Sep. 1, 1994The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula (I) a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein X and Y each independently are CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; Z is C=O or CHOH; and Ar is phenyl optionally substituted with up to three substituents selected from hydroxy, C1-4alkyl, C1-4alkyloxy, halo, trifluoromethyl, triC1-4alkylsilyloxy, nitro, amino and cyano or pyridinyl substituted with hydroxy or C1-4alkyloxy; and -A- is a radical of formula (a-1) (a-2) (a-3) (a-4) (a-5) (a-6) or (a-7)</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyr0KwjAUQOEsDqK-w30Bh1JR1_zc2EBIJPemUJdSJE6ihfr-mMEHcDrDd9YiU1bEjjOjAYPJ9ZJdjwTRgrxFHwOCjQkyIbgAnLB6uIBxhJLqp2UlA2qADr2LSmrGtBWrx_Rcyu7XjQCLrLt9md9jWebpXl7lM159czqc26NSTfvH8gUglTBR</recordid><startdate>19980930</startdate><enddate>19980930</enddate><creator>VAN DER EYCKEN LUC A. L</creator><creator>ODDS FRANK C</creator><creator>STOKBROEKX RAYMOND A</creator><creator>HEERES JAN</creator><creator>VAN DER AA MARCEL J. M</creator><creator>MOSTMANS JOSEPH H</creator><scope>EVB</scope></search><sort><creationdate>19980930</creationdate><title>SUBSTITUTED DERIVATIVES OF AZOLONE FOR USE IN TREATING DISEASES CAUSED BY HELIOBACTER</title><author>VAN DER EYCKEN LUC A. L ; ODDS FRANK C ; STOKBROEKX RAYMOND A ; HEERES JAN ; VAN DER AA MARCEL J. M ; MOSTMANS JOSEPH H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PL174836BB13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; pol</language><creationdate>1998</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>VAN DER EYCKEN LUC A. L</creatorcontrib><creatorcontrib>ODDS FRANK C</creatorcontrib><creatorcontrib>STOKBROEKX RAYMOND A</creatorcontrib><creatorcontrib>HEERES JAN</creatorcontrib><creatorcontrib>VAN DER AA MARCEL J. M</creatorcontrib><creatorcontrib>MOSTMANS JOSEPH H</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VAN DER EYCKEN LUC A. L</au><au>ODDS FRANK C</au><au>STOKBROEKX RAYMOND A</au><au>HEERES JAN</au><au>VAN DER AA MARCEL J. M</au><au>MOSTMANS JOSEPH H</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED DERIVATIVES OF AZOLONE FOR USE IN TREATING DISEASES CAUSED BY HELIOBACTER</title><date>1998-09-30</date><risdate>1998</risdate><abstract>PCT No. PCT/EP94/00380 Sec. 371 Date Jul. 18, 1995 Sec. 102(e) Date Jul. 18, 1995 PCT Filed Feb. 9, 1994 PCT Pub. No. WO94/18978 PCT Pub. Date Sep. 1, 1994The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula (I) a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein X and Y each independently are CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; Z is C=O or CHOH; and Ar is phenyl optionally substituted with up to three substituents selected from hydroxy, C1-4alkyl, C1-4alkyloxy, halo, trifluoromethyl, triC1-4alkylsilyloxy, nitro, amino and cyano or pyridinyl substituted with hydroxy or C1-4alkyloxy; and -A- is a radical of formula (a-1) (a-2) (a-3) (a-4) (a-5) (a-6) or (a-7)</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; pol |
| recordid | cdi_epo_espacenet_PL174836BB1 |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED DERIVATIVES OF AZOLONE FOR USE IN TREATING DISEASES CAUSED BY HELIOBACTER |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T19%3A17%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=VAN%20DER%20EYCKEN%20LUC%20A.%20L&rft.date=1998-09-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EPL174836BB1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |