SUBSTITUTED DERIVATIVES OF AZOLONE FOR USE IN TREATING DISEASES CAUSED BY HELIOBACTER

PCT No. PCT/EP94/00380 Sec. 371 Date Jul. 18, 1995 Sec. 102(e) Date Jul. 18, 1995 PCT Filed Feb. 9, 1994 PCT Pub. No. WO94/18978 PCT Pub. Date Sep. 1, 1994The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula (I) a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein X and Y each independently are CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; Z is C=O or CHOH; and Ar is phenyl optionally substituted with up to three substituents selected from hydroxy, C1-4alkyl, C1-4alkyloxy, halo, trifluoromethyl, triC1-4alkylsilyloxy, nitro, amino and cyano or pyridinyl substituted with hydroxy or C1-4alkyloxy; and -A- is a radical of formula (a-1) (a-2) (a-3) (a-4) (a-5) (a-6) or (a-7)