METHOD OF OBTAINING NOVEL DERIVATIVES OF 1,3-DIHYDRO-2H(4,5-B)QUINOLIN IMIDAZONE-2

Novel 1,3-dihydro-2H-imidazoÄ4,5-bÜquinolin-2-one derivatives of formula wherein R is hydrogen, C PI 1/4 alkyl, C PI 1/4 cycloalkyl, phenyl optionally substituted with from 1 to 3 substituents each independently selected from halo, hydroxy, C PI 1/4 alkyloxy, C psi PI 1/4 cycloalkyloxy, C PI 1/4 alkyl or trifluoromethyl; pyridinyl; thienyl optionally substituted with halo or C PI 1/4 alkyl; and +C=X is a radical of formula +C=O (a), +C=N-O-R (b), or +C=CH-R (c); the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, said compounds being potent inhibitors of both phosphodiesterase III and IV, which are useful in the treatment of allergic disorders, atopic diseases and related afflictions. Intermediates in the preparation thereof. Pharmaceutical compositions containing said compounds as an active ingredient. Methods of preparing said compounds and pharmaceutical compositions.