METHOD OF OBTAINING NOVEL DERIVATIVES OF THIAZOLYLHYDRAZIDES

This invention relates to novel triazolyl hydrazide derivatives and a process for the preparation thereof. The new triazolyl hydrazide derivatives of the general formula (I), wherein Q represents hydrogen or a heterocyclic group optionally substituted by a C1-4 alkyl group; or a group of the formula SR , wherein R stands for C1-4 alkyl or phenyl-(C1-4 alkyl), or a group of the formula NR R , wherein R and R each represent hydrogen, straight or branched chained C1-6 alkyl or C2-6 alkenyl; Z represents hydrogen or a group of the formula (C=X)-(N-R )-NR R , wherein X stands for oxygen or sulfur, R , R and R each stand for hydrogen or C1-4 alkyl; R denotes hydrogen, C1-4 alkyl or phenyl-(C1-4 alkyl) optionally substituted by one or more halogen atom(s), R stands for hydrogen or a group of the formula -(C=X)-(N-R )-NR R , wherein X, R , R and R are as stated above, with the proviso that if Z represents a group of the formula -(C=X)-(N-R )-NR R , R stands for hydrogen, and if Z represents hydrogen, R stands for a group of the formula (C=X)-(N-R )-NR R , and pharmaceutically acceptable acid addition salts thereof exert valuable antianginal and/or gastric ulcer inhibiting properties and are useful in therapy.