PRODUCT CONTAINING AT LEAST ONE PHOSPHATASE CDC25 INHIBITOR COMBINED WITH AT LEAST ONE OTHER ANTICANCER AGENT

PRODUCT CONTAINING AT LEAST ONE PHOSPHATASE CDC25 INHIBITOR COMBINED WITH AT LEAST ONE OTHER ANTICANCER AGENT

Composition comprises at least one Cdc25 phosphatase inhibitor (I) in combination with at least one other anticancer agent (II), for simultaneous, separate or successive use in the treatment of cancer. ACTIVITY : Cytostatic. In tests for inhibition of proliferation of HT-29 (human colon cancer) cell...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BREZAK PANNETIER, MARIERISTINE, PREVOST, GRÉGOIRE
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Composition comprises at least one Cdc25 phosphatase inhibitor (I) in combination with at least one other anticancer agent (II), for simultaneous, separate or successive use in the treatment of cancer. ACTIVITY : Cytostatic. In tests for inhibition of proliferation of HT-29 (human colon cancer) cells in vitro, the degree of cell survival after 6 days was 36% in presence of 1 MicroM 5-((2-(dimethylamino)-ethyl)-amino)-2-methyl-1,3-benzothiazole-4,7-dione (Ia) (as the hydrochloride), 44% in presence of 50 MicroM roscovitine (IIa) and 0% in presence of a combination of 1 MicroM (Ia) and 50 MicroM (IIa). MECHANISM OF ACTION : Cdc25 phosphatase inhibitor.